Urokinase

Identification

Name
Urokinase
Accession Number
DB00013 / 83G67E21XI
Groups
Kinlytic
Description

Low molecular weight shape of human urokinase, that consists of an a chain of two,000 daltons connected by way of a sulfhydryl bond to a B chain of 30,four hundred daltons. Recombinant urokinase plasminogen activator.

Pharmacology

Pharmacodynamics

Urokinase is used for the treatment of pulmonary embolisms. The low molecular weight form of human urokinase consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Urokinase is an enzyme (protein) produced by the kidney, and found in the urine. There are two forms of urokinase which differ in molecular weight but have similar clinical effects. Urokinase is the low molecular weight form. Urokinase acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen and some other plasma proteins.

Indication

Urokinase can be used for the treatment of pulminary embolism, coronary artery thrombosis, IV catheter clearance, and venous and arterial blood clots.

Action

Urokinase acts on the endogenous fibrinolytic system. It cleaves the Arg-Val bond in plasminogen to produce active plasmin. Plasmin degrades fibrin clots as well as fibrinogen and other plasma proteins.