Testosterone propionate is a slower releasing anabolic steroid with a short half-life. This feature allows the consumer to run short testosterone propionate cycles of eight-10 weeks as ideal height blood plasma tiers are done at 2-four weeks.[L1159] it is a artificial androstane steroid derivative of testosterone in the form of 17Î² propionate ester of testosterone.[T83] Testosterone propionate became evolved to start with by using Watson labs, and FDA accredited on February 5, 1974. presently, this drug has been discontinued in human beings, however the vet software continues to be available as an OTC.[L1160]
The administration of testosterone propionate can induce production of proteins related to male sexual development.[L1162] On the other hand, testosterone itself present an estrogenic activity due to interaction with aromatase enzyme, thus the continuous aministration of testosterone propionate may cause the elevation of plasma estrogen.[L1161] Clinical trials showed as well, a decrease in plasma LH after testosterone propionate administration.[A31625]
Testosterone propionate is often used for muscle mass building. The original medical indication is for the treatment of androgen deficiency in male adults either in hypogonadism or andropause.[L1161] Nowadays testosterone propionate is indicated for its use in heifers in order to stimulate maximal growth.[L1160]
The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5alpha-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5alpha-reductase. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.