Sermorelin

Identification

Name
Sermorelin
Accession Number
DB00010 / 89243S03TE
Groups
Description

Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal section of the evidently taking place human boom hormone-liberating hormone (GHRH or GRF) including forty four amino acid residues

Pharmacology

Pharmacodynamics

Sermorelin is used in the treatment of children with growth hormone deficiency or growth failure. Geref increases plasma growth hormone (GH) concentration by stimulating the pituitary gland to release GH. Geref is similar to the full-length native hormone (44 residues) in its ability to stimulate GH secretion in humans.

Indication

For the treatment of dwarfism, prevention of HIV-induced weight loss

Action

Sermorelin binds to the growth hormone releasing hormone receptor and mimics native GRF in its ability to stimulate growth hormone secretion.