Rasburicase

Identification

Name
Rasburicase
Accession Number
DB00049 / 08GY9K1EUO
Groups
Elitek
Description

Rasburicase is a recombinant urate-oxidase enzyme produced with the aid of a genetically changed <i>Saccharomyces cerevisiae</i> strain. The cDNA coding for rasburicase become cloned from a pressure of _Aspergillus flavus_.

Pharmacology

Pharmacodynamics

Drugs used to treat lympohoid leukemia, non-Hodgkin's lymphoma and acute myelogenous leukemia often lead to the accumulation of toxic plasma levels of purine metabolites (i.e. uric acid). The injection of rasburicase reduces levels of uric acid and mitigates the toxic effects of chemotherapy induced tumor lysis.

Indication

For treatment of hyperuricemia, reduces elevated plasma uric acid levels (from chemotherapy)

Action

Rasburicase catalyzes enzymatic oxidation of uric acid into an inactive and soluble metabolite (allantoin).