Pegaspargase

Identification

Name
Pegaspargase
Accession Number
DB00059 / 7D96IR0PPM
Groups
Oncaspar
Description

Pegylated L-asparagine amidohydrolase from E. coli. Pegylation significantly (via a element of four) extends the protein half life.

Pharmacology

Pharmacodynamics

In a significant number of patients with acute leukemia, the malignant cells are dependent on an exogenous source of asparagine for survival. Normal cells, however, are able to synthesize asparagine and thus are affected less by the rapid depletion produced by treatment with the enzyme asparaginase. Oncaspar exploits a metabolic defect in asparagine synthesis of some malignant cells.

Indication

For treatment of acute lymphoblastic leukemia

Action

Pegaspargase, more effective than asparaginase, converts asparagine to aspartic acid and ammonia. It facilitates production of oxaloacetate which is needed for general cellular metabolism. Some malignant cells lose the ability to produce asparagine and so the loss of exogenous sources of asparagine leads to cell death.