Pegademase

Identification

Name
Pegademase
Accession Number
DB00061 / HW3H7D91F6
Groups
Adagen
Description

Bovine adenosine deaminase derived from bovine gut that has been extensively pegylated for extended serum half of existence.

Pharmacology

Pharmacodynamics

Used to replace deficient or inactive adenosine deaminase which leads to severe combined immunodeficiency disease (SCID). The enzyme is responsible for converting adenosine to inosine. In the absence of adenosine deaminase, the purine substrates adenosine, 2'-deoxyadenosine and their metabolites are actually toxic to lymphocytes thereby leading to diminished immune function.

Indication

For treatment of adenosine deaminase deficiency

Action

Pegademase converts adenosine (toxic) to inosine (less toxic) by deamination. It also converts 2'-deoxyadenosine to 2'-deoxyinosine via deamination.