Pancrelipase

Identification

Name
Pancrelipase
Accession Number
DB00085 / FQ3DRG0N5K
Groups
Alka-pan Tablets
Description

Pancrelipase, in widespread, consists of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. these enzymes are extracted from porcine pancreatic glands.[L2509] The pancrelipase aggregate became developed via Ortho-McNeil-Janssen prescribed drugs, Inc and FDA authorised on April 12, 2010.[L2510] For similarly records at the components of this mixture please visit [DB11065], [DB11066] and [DB13147].

Pharmacology

Pharmacodynamics

The major maldigestion/malabsorption problems arise from incomplete fat digestion. In clinical trials, the administration of pancrelipase as a mixture of amylase, lipase, and protease demonstrated a significant improvement in the coefficient of fat absorption and nitrogen absorption. These effects are accompanied by increased in body weight and body mass index.[A32721]

Indication

The use of pancrelipase amylase is part of the pancreatic enzyme replacement therapy. This therapy is indicated for the treatment of pancreatic insufficiency attributed to cystic fibrosis, chronic pancreatitis or any other medically defined pancreatic disease that might require it.[A32721, A32736] Pancreatic diseases are associated with the deterioration of pancreatic parenchyma and of the dual physiological functions of the pancreas. Once established, pancreatic insufficiency results in malnutrition, weight loss, and steatorrhea.[A32723]

Action

Pancrelipase is used to replace the deficiency of pancreatic enzymes. As abovementioned, pancrelipase is formed by a mixture of lipase, protease, and amylase which are able to break down fat, protein, and starches, respectively, in the small intestine.[T180] For a more specific description of each mechanism of action, please visit [DB11065], [DB11066] and [DB13147].