Muromonab

Identification

Name
Muromonab
Accession Number
DB00075 / JGA39ICE2V
Groups
Okt3
Description

Murine monoclonal antibody specific to CD3 T-mobile lymphocyte antigens. extra particularly it's far a purified murine (mouse) monoclonal antibody, directed towards the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured the usage of the murine ascites method. Muromonab is ninety three% monomeric immune globulin G kind 2a (IgG2a).

Pharmacology

Pharmacodynamics

Used in organ transplant prophylaxis, Muromonab or OKT-3 binds specifically to the CD-3 complex, which is involved in antigen recognition and cell stimulation, on the surface of T lymphocytes. Immediately after administration CD-3-positive T lymphocytes are abruptly removed from circulation. It has been effective in reversing corticosteroid-resistant acute rejection in renal, liver, and cardiac transplant recipients.

Indication

For treatment of organ transplant recipients, prevention of organ rejection

Action

Muromonab binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.