Menotropins

Identification

Name
Menotropins
Accession Number
DB00032 / 5Y9QQM372Q
Groups
Menopur
Description

Menotropins contains follicle stimulating hormone (FSH) and luteinizing hormone (LH) purified from the urine of postmenopausal women. it is used as a fertility medicine this is injected either subcutaneously or intramuscularly. it's miles composed of LH with 2 subunits, alpha = ninety two residues, beta = 121 residues and FSH with 2 subunits, alpha = 92 residues, beta=111 residues.

Pharmacology

Pharmacodynamics

Used to treat female infertility, Menotropins stimulates late follicular maturation and resumption of oocyte meiosis, and initiates rupture of the pre-ovulatory ovarian follicle. Menotropins bind to the LH/hCG/FSH receptor of the granulosa and theca cells of the ovary to effect these changes in the absence of an endogenous LH surge.

Indication

For the treatment of female infertility

Action

Being a combination drug, Menotropins bind to the follicle stimulating hormone receptor (FSH), which results in ovulation in the absence of sufficient endogenous luteinizing hormone (LH). It also binds the LH receptor, thereby stimulating proper hormone release. The drug contains both FSH and LH, therefore, it induces ovarian follicular growth and development as well as gonadal steroid production in women who do not have ovarian failure. FSH is the primary driver of follicular recruitment and growth in early folliculogenesis, while LH is important for ovarian steroidogenesis and is involved in the physiological events leading to development of a competent pre-ovulatory follicle.