Lepirudin

Identification

Name
Lepirudin
Accession Number
DB00001 / Y43GF64R34
Groups
Refludan
Description

Lepirudin is equal to natural hirudin except for substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate institution on the tyrosine at position 63. it is produced thru yeast cells. Bayer ceased the manufacturing of lepirudin (Refludan) effective may additionally 31, 2012.

Pharmacology

Pharmacodynamics

Lepirudin is used to break up clots and to reduce thrombocytopenia. It binds to thrombin and prevents thrombus or clot formation. It is a highly potent, selective, and essentially irreversible inhibitor of thrombin and clot-bond thrombin. Lepirudin requires no cofactor for its anticoagulant action. Lepirudin is a recombinant form of hirudin, an endogenous anticoagulant found in medicinal leeches.

Indication

For the treatment of heparin-induced thrombocytopenia

Action

Lepirudin forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen and initiate the clotting cascade. The inhibition of thrombin prevents the blood clotting cascade.