Interferon alfa-n3

Identification

Name
Interferon alfa-n3
Accession Number
DB00018 / 47BPR3V3MP
Groups
Alferon
Description

Purified, herbal (n is for herbal) human interferon alpha proteins (consists of 3 paperwork or polymorphisms which include 2a, 2b and 2c). 166 residues, some are glycosylated (MW range from 16 kD to 27 kD).

Pharmacology

Pharmacodynamics

Interferon alfa-n3 upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase), beta-2 microglobulin, neopterin and protein kinase R.

Indication

For the intralesional treatment of refractory or recurring external condylomata acuminata.

Action

Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription) which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.