Hyaluronidase (ovine)

Identification

Name
Hyaluronidase (ovine)
Accession Number
DB00070 / 64R4OHP8T0
Groups
Vitrase
Description

relatively purified sheep hyaluronidase for management with the aid of injection into the vitreous of the eye.

Pharmacology

Pharmacodynamics

Hyaluronidase hydrolyzes hyaluronic acid and increase diffusion of injected drugs, thus facilitating their absorption. Hyaluronidase is used for enhancing absorption and distribution of other injected drugs.

Indication

For increase of absorption and distribution of other injected drugs and for rehydration.

Action

Hyaluronidase is a spreading or diffusing substance. It increase the permeability of connective tissue through the hydrolysis of hyaluronic acid. Hyaluronidase hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid. This temporarily decreases the viscosity of the cellular cement and increases diffusion of injected fluids or of localized transudates or exudates, thus facilitating their absorption.