Gramicidin D

Identification

Name
Gramicidin D
Accession Number
DB00027 / 5IE62321P4
Groups
Antibiotic Cream
Description

Gramcidin D is a heterogeneous aggregate of three antibiotic compounds, gramicidins A, B and C, making up eighty%, 6%, and 14% respectively all of which can be acquired from the soil bacterial species Bacillus brevis and referred to as together gramicidin D. Gramcidins are 15 residue peptides with alternating D and L amino acids. The peptides gather internal of the hydrophobic indoors of the cell lipid bilayer to form a β-helix. The helix itself isn't long enough to span the membrane however it dimerizes to shape the elongated channel needed to span the entire membrane. Gramicidin D is used normally as a topical antibiotic and is one of the 3 constituents of client antibiotic polysporin ophthalmic answer.

Pharmacology

Pharmacodynamics

Gramicidin is particularly effective against gram-positive bacteria. Because the drug is highly hemolytic, it cannot be administered internally and so is used only on the skin as a lotion or ointment. It is used primarily in the treatment of infected surface wounds, and in eye, nose, and throat infections. It is normally given with two other antibiotics (neomycin and polymixin B) as an ophthalmic solution.

Indication

For treatment of skin lesions, surface wounds and eye infections.

Action

Gramicidin D binds to and inserts itself into bacterial membranes (with a strong preference to gram-positive cell membranes). This results in membrane disruption and permeabilization (it acts as a channel). This leads to (i) loss of intracellular solutes (e.g., K+ and amino acids); (ii) dissipation of the transmembrane potential; (iii) inhibition of respiration; (iv) a reduction in ATP pools; and (v) inhibition of DNA, RNA, and protein synthesis, which leads to cell death.