Goserelin

Identification

Name
Goserelin
Accession Number
DB00014 / 0F65R8P09N
Groups
Zoladex
Description

Goserelin is a synthetic hormone. In guys, it stops the manufacturing of the hormone testosterone, which may additionally stimulate the growth of most cancers cells. In women, goserelin decreases the manufacturing of the hormone estradiol (which might also stimulate the increase of most cancers cells) to tiers much like a postmenopausal country. when the drugs is stopped, hormone degrees go back to ordinary.

Pharmacology

Pharmacodynamics

The pharmacokinetics of goserelin have been determined in both male and female healthy volunteers and patients. In these studies, goserelin was administered as a single 250µg (aqueous solution) dose and as a single or multiple 3.6 mg depot dose by subcutaneous route.

Indication

Used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty.

Action

Goserelin is a synthetic decapeptide analogue of LHRH. Goserelin acts as a potent inhibitor of pituitary gonadotropin secretion when administered in the biodegradable formulation. The result is sustained suppression of LH and serum testosterone levels.