Follitropin

Identification

Name
Follitropin
Accession Number
DB00066 / 076WHW89TW
Groups
Bemfola
Description

Follitropin is a human follicle stimulating hormone (FSH) preparation of recombinant DNA starting place, which includes two non-covalently linked, non-equal glycoproteins exact because the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn fifty one and Asn seventy eight even as the beta subunit is glycosylated at Asn 7 and Asn 24. Follitropin beta is produced in genetically engineered chinese hamster cell traces (CHO). The nomenclature “beta” differentiates it from another recombinant human FSH product that became advertised earlier as follitropin alpha. Follitropin is crucial within the development of follicles produced via the ovaries. Given via subcutaneous injection, it's far used in aggregate with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Follitropin can also be used to reason the ovary to produce several follicles, that can then be harvested to be used in gamete intrafallopian transfer (present) or in vitro fertilization (IVF). severa physio-chemical assessments and bioassays indicate that follitropin beta and follitropin alpha are indistinguishable. but, a more recent study confirmed there is may be a moderate scientific difference, with the alpha form tending towards a higher pregnancy price and the beta shape tending towards a lower being pregnant rate, but with significantly higher estradiol (E2) levels. Structural evaluation shows that the amino acid sequence of follitropin beta is equal to that of herbal human follicle stimulating hormone (FSH). similarly, the ogliosaccharide side chains are very comparable, however now not absolutely identical to that of herbal FSH. however, these small variations do not have an effect on the bioactivity as compared to natural FSH.

Pharmacology

Pharmacodynamics

Used for the treatment of female infertility, Follitropin beta or follicle stimulating hormone (FSH) stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component of Follitropin beta is the primary hormone responsible for follicular recruitment and development.

Indication

In women having been diagnosed with primary ovarian failure, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. In men with hypogonadotrophic hypogonadism, it is used to induce spermatogenesis. Follitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF).

Action

Follitropin is a recombinant form of endogenous follicle stimulating hormone (FSH). FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.