Drotrecogin alfa

Identification

Name
Drotrecogin alfa
Accession Number
DB00055 / JGH8MYC891
Groups
Xigris
Description

Drotrecogin alfa is activated human protein C this is synthesized with the aid of recombinant DNA technology. it's far a glycoprotein of approximately fifty five kilodalton molecular weight, which include a heavy chain and a mild chain linked via a disulfide bond. Drotrecogin alfa turned into withdrawn from the marketplace after a prime observe indicated that it become not powerful in enhancing effects in sufferers with sepsis.

Pharmacology

Pharmacodynamics

Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa inhibits factor Va and VIIIa, thereby reducing the coagulability of blood.

Indication

For reduction of mortality in patients with severe sepsis.

Action

Activated protein C combines with protein S on platelet surfaces and then degrades factor Va and factor VIIIa, thereby reducing blood coagulability.