Digoxin Immune Fab (Ovine)

Identification

Name
Digoxin Immune Fab (Ovine)
Accession Number
DB00076 / YB12NQZ1YN
Groups
Digibind
Description

Digoxin Immune Fab is a sheep antibody (26-10) FAB fragment from sheep immunized with the digoxin by-product Digoxindicarboxymethylamine. it's miles used as an antidote for overdose of digoxin.

Pharmacology

Pharmacodynamics

DigiFab binds molecules of digoxin, making them unavailable for binding at their site of action on cells in the body. The Fab fragment-digoxin complex accumulates in the blood, from which it is excreted by the kidney. The net effect is to shift the equilibrium away from binding of digoxin to its receptors in the body, thereby reversing its effects.

Indication

For treatment of digitoxin overdose or digitalis glycoside toxicity.

Action

Binds excess digoxin or digitoxin molecules circulating in the blood.