Daptomycin

Identification

Name
Daptomycin
Accession Number
DB00080 / NWQ5N31VKK
Groups
Cubicin
Description

Daptomycin is a lipopeptide antibiotic that kills prone gram wonderful bacteria by means of disrupting their membrane potential. it's far a naturally-taking place compound discovered inside the soil bacterium <i>Streptomyces roseosporus</i>. Antibiotics are used in the remedy of infections as a result of micro organism. They paintings by using killing bacteria or preventing their growth. Daptomycin will not paintings for colds, flu, or different virus infections. It became accredited in September 2003 for the treatment of complicated pores and skin and gentle tissue infections. It has a protection profile much like different agents generally administered to treat gram-wonderful infections.

Pharmacology

Pharmacodynamics

Daptomycin is a 13 member amino acid cyclic lipopeptide antibiotic active against Gram-positive bacteria only. It has proven in vitro activity against enterococci (including glycopeptide-resistant Enterococci (GRE)), staphylococci (including methicillin-resistant <i>Staphylococcus aureus</i>), streptococci and corynebacteria. Daptomycin is derived from the fermentation product of Streptomyces roseosporus.

Indication

For the treatment of complicated skin and skin structure infections caused by susceptible strains of Gram-positive microorganisms.

Action

Daptomycin appears to bind or insert into the outer membrane of gram positive bacteria. The binding and integration of daptomycin into the cell membrane is calcium dependent. Calcium ions cause a conformational change in daptomycin, augmenting its amphipathicity (hydrophilic head group and hydrophobic tail group), leading to incorporation into the cell membrane. This binding causes rapid depolarisation, resulting in a loss of membrane potential leading to inhibition of protein, DNA and RNA synthesis, which results in bacterial cell death. The bactericidal activity of daptomycin is concentration-dependent. There is in vitro evidence of synergy with β-lactam antibiotics.