Recombinant human coagulation element VIIa (rFVIIa), meant for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade. NovoSeven is a nutrition ok-dependent glycoprotein inclusive of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically energetic in a -chain form.
Used in the treatment of bleeding episodes in hemophilia A or B. NovoSeven is recombinant Factor VIIa and, when complexed with tissue factor can activate coagulation Factor X to Factor Xa, as well as coagulation Factor IX to Factor IXa. Factor Xa, in complex with other factors, then converts prothrombin to thrombin, which leads to the formation of a hemostatic plug by converting fibrinogen to fibrin and thereby inducing local clotting.
For treatment of hemorrhagic complications in hemophilia A and B
NovoSeven activates the coagulation or clotting cascade by cleaving Factor IX and Factor X, which activates them and then leads to activation of thrombin and fibrin.