Cetrorelix

Identification

Name
Cetrorelix
Accession Number
DB00050 / OON1HFZ4BA
Groups
Cetrotide
Description

Cetrorelix is a person-made hormone that blocks the outcomes of Gonadotropin releasing Hormone (GnRH). GnRH controls some other hormone this is known as luteinizing hormone (LH), that is the hormone that starts offevolved ovulation for the duration of the menstrual cycle. while undergoing hormone treatment sometimes untimely ovulation can occur, main to eggs that aren't prepared for fertilization to be released. Cetrorelix does not allow the untimely release of those eggs to occur.

Pharmacology

Pharmacodynamics

Cetrorelix is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently luteinization as indicated by rising progesterone levels. Cetrorelix competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner.

Indication

For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation

Action

Cetrorelix binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion. It competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner.