Antithymocyte immunoglobulin (rabbit)

Identification

Name
Antithymocyte immunoglobulin (rabbit)
Accession Number
DB00098 / D7RD81HE4W
Groups
Thymoglobulin
Description

Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses positive kinds of immune cells answerable for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies meant to bind to various cellular surface antigens. The maximum not unusual mode of movement of Thymoglobulin is through selective depletion of T-cells.

Pharmacology

Pharmacodynamics

Antithymocyte Globulin (ATG) is a concentrated anti-human T-lymphocyte immunoglobulin preparation derived from rabbits after immunization with a T-lympoblast cell line. ATG is an immunosuppressive product for the prevention and treatment of acute rejection following organ transplantation. ATG reduces the host immune response against tissue transplants or organ allografts.

Indication

For prevention of renal transplant rejection

Action

Binds to multiple, T-cell specific antigens leading to T-lymphocyte cell death via complement mediated cytotoxicity or apoptosis.