Antihemophilic factor, human recombinant

Identification

Name
Antihemophilic factor, human recombinant
Accession Number
DB00025 / P89DR4NY54
Groups
Advate
Description

Human recombinant antihemophilic thing (AHF) or element VIII, 2332 residues, glycosylated, produced by using CHO cells

Pharmacology

Pharmacodynamics

Antihemophilic Factor binds factor IXa along with calcium and phospholipid, This complex converts factor X to factor Xa to facilitate clotting cascade.

Indication

For the treatment of hemophilia A, von Willebrand disease and Factor XIII deficiency.

Action

Antihemophilic factor (AHF) is a protein found in normal plasma which is necessary for clot formation. The administration of AHF provides an increase in plasma levels of AHF and can temporarily correct the coagulation defect of patients with hemophilia A (classical hemophilia).