Anistreplase

Identification

Name
Anistreplase
Accession Number
DB00029 / 5O8V541HJ6
Groups
Eminase 30 Units
Description

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) components of anistreplase, the p-anisoyl by-product of the number one Lys-plasminogen-streptokinase activator complex (a complicated of Lys-plasminogen and streptokinase). A p-anisoyl institution is chemically conjugated to a complicated of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins.

Pharmacology

Pharmacodynamics

Anistreplase cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction.

Indication

For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction

Action

Anistreplase cleaves the Arg/Val bond in plasminogen to form plasmin. This in turn leads to the degradation of blood clots.