Alteplase

Identification

Name
Alteplase
Accession Number
DB00009 / 1RXS4UE564
Groups
Activase
Description

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells

Pharmacology

Pharmacodynamics

Alteplase binds to fibrin in a thrombus and converts the entrapped plasminogen to plasmin. It also produces limited conversion of plasminogen in the absence of fibrin.

Indication

For management of acute myocardial infarction, acute ischemic strok and for lysis of acute pulmonary emboli

Action

Alteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.